PPT Slide
- Evaluate gene and protein expression profiles in standardized in vivo and in vitro test systems following exposure to well characterized toxicants with known mechanisms of action
- build a repository of expression data
- share knowledge and experience of methods
- determine range and extent of variability
- determine influence of experimental variables on range of variability
- determine the need for standardization
- relate changes in gene and protein expression to other measures of toxicity
- establish a basis for interpretation of expression data
Application of Genomics and Proteomics to Mechanism-Based Risk Assessment Mission, Goals and Objectives